Seeking Health P-5-P (Pyridoxal 5-Phosphate) - Immune Health & Homocysteine Metabolism Support - Support Energy Production with Bioavailable Vitamin B6-25, 100 Capsules

My 13 year old takes this - as recommended by his doctor. He experiences no side effects for it and we feel good about the quality of the product. Very reasonable price for such quality from Dr Ben!

Really really great product. Working for me super well

Absolutely solid P5P brand. Definitely helped manage my prolactin levels while on TRT. Would like to mention I did not go guns blazing with dosage. I took it very slow while seeing how my body reacts. Overall mood and sleep are the greatest things that improved! Would highly recommend giving this a shot if you’re in the same boat.

New research Oct 2017 study (The Vitamin B6 Paradox) on Researchgate showed that taking the pyridoxine form of b6 in larger doses actually leads to decreased vitamin b6 function and symptoms of deficiency. The inactive form pyridoxine competitively inhibits the active pyridoxal-5-phosphate form and both pyridoxal 5 phosphate dependent enzymes were inhibited by pyridoxine. So the more pyridoxine you take, the more it can work against you and even lead to deficiency B6 symptoms. It also mentions it was toxic even at lower doses killing cells, and Lareb reported that some found doses as low as 2mg/day caused the same neuropathy symptoms as higher doses. This product is Pyrodoxal-5-phosphate, the active form which doesnt have any of those issues, and so in my opinion seems to be the better way to supplement vitamin b6 and why I chose it and now avoid pyridoxine as much as I can. Vitamin B6 in the non active form also needs Magnesium, Zinc, and Vitamin B2 to convert to its active form. As many are low on magnesium, or are under stress which depletes both magnesium and zinc, it seems that many may not be converting Vitamin B6 as well. There are also genetic mutations MTHFR that some may have that can keep the conversion from occuring. Seeking Health is a high quality brand, and this B6 does not have many of the fillers others do. I would buy again anytime I need a standalone B6 supplement. I also use their Seeking Health B Minus which has 20mg P5P with the other B vitamins except B12 and also Folate, which can be added separate as needed. Has my review been of help to you? If so, would you consider hitting the "helpful" button below? I'd greatly appreciate it. Thank you!

As a certified nutrition coach who specializes in MTHFR, Hashimotos and inflammation P5P is the only form of B6 that I recommend to my clients and anyone with MTHFR variants. Seeking Health is also one of the brands I trust and often recommend to clients and followers on Social Media.

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Good

Good value