Nootropics DepotBerberine HCL + Silymarin Capsules | 500mg + 90mg | 60 Count | Supports Cellular Function, Metabolic Function

I bought berberine from another supplier and experienced air hunger and suppressed breathing. So I trust ND more so I bought theirs and experienced the same thing but just as strong with a half dose. So I guess the issue is berberine and the previous suppliers berberine was bunk…. So a win for ND ?!? Anyway I’m not a diabetic and don’t have high blood sugar at all so i guess the lesson is. Don’t use berberine to optimize health or blood sugar. But if you are this is a good one

First, berberine is a scientifically backed supplement, but it is difficult to find brands that are proven, trustworthy, & 3rd party verified. Nootropics Depot is simply one of the best supplement manufacturers that you can buy anywhere. I trust them wholly, I’ve done what some would call an extreme amount of research on dozens of supplement brands & supplements, nootropics, nutraceuticals, etc. I am a 4th year graduate student in the field of dietetics/nutritional research, & I am very impressed by the quality, accuracy/precision, honesty & scientifically researched compounds that Nootropics Depot offers. The first hurdle is finding a superior supplement brand, now let’s talk about berberine.Berberine has been evidenced in peer-reviewed, longitudinal studies and/or meta-analyses:1. To be an effective treatment for type 2 diabetes, performing similarly to Metformin (a diabetes medication). It reduced hemoglobin A1c (HbA1c) levels, fasting blood glucose, blood glucose following a meal, triglycerides levels, reduced plasma insulin, reduced total cholesterol & LDL.Berberine can directly increase AMPK, which stimulates glucose uptake in muscle cells and helps balance high blood sugar, delay the breakdown of carbohydrates into simple sugars, enhance glucagon secretion, mimics insulin action by increasing the ability of the body to take up glucose, increases adiponectin, a protein which helps regulate blood sugar levels (through AMPK), activates the blood sugar transport activity of glucose transporter 1 (GLUT1), activates the fatty acid receptor GPR40, protects the beta-cells of the pancreas against cell death, improves the gut microbiota, inhibits NF-kappaB (NF-kB), etc.2. Berberine may aid in weight loss (for me, I noticed significant weight loss from berberine after I had gained weight on an MAOI drug despite working out frequently.)3. Berberine is anti-parasitic, helps boost the immune system, is anti-bacterial, anti-fungal, may help prevent heart disease, protects the liver, improves mitochondrial function, lowers blood pressure, & has shown evidence for anti-anxiety & reduction of depression systems by elevating key neurotransmitters in the frontal cortex.One caveat I will mention is that berberine can interfere with certain aspects of athletic performance, simply put, Berberine (like Metforin) should be taken several hours after working out or only on non-workout days, or on off days from intense training or weight lifting. I take Berberine at night, at least 6 hours after exercise or skip a dosage if I’ve done intense weight training that day.I love Berberine because it helped me shed extra pounds that were a side effect of an MAOI medication I am on. The drug is very effective but unfortunately causes weight gain very quickly & easily even with a good diet & intense exercise. When I finally added 750-1000mg of Berberine at night (generally after my largest meal of the day), I saw rapid weight loss back down to my normal toned weight prior to me taking the MAOI drug. Just as quickly as I went from 170lbs with a 7.6% body fat, after the MAOI shot me up to 194lbs despite a balanced diet & exercise, once I added Berberine, I quickly came back down to 171lbs 7.4% body fat.

Good company, but if using Berberine for weight management be aware that milk thistle / Silymarin can increase appetite which is counterproductive to why people take Berberine.I was ravenous (blood sugar wasn’t low).After research I found out milk thistle is used for elderly to increase their appetite.I needed this for weight management.Will have to stick to my other source.However, as a company, nootropics Depot quality is unbeatable.

This is probably the best berberine product of its kind. It’s also one of the most expensive… You get what you pay for. I really like this company.

This combination of berberine with an additive did a number on my GI tract. I was angry at first when Amazon said the prodcut was not refundable.. but i wrote the company and theyy actually stepped in and refunded my money through amazon. That is more than fair.

If I could give this product 10 stars I would. I have been taking this product and I feel energy and I am also noticing some pains that I was feeling are no longer painful. I will continue to use this product and I plan to share this information with family members.

Bottle wasn’t secured and had came out of plastic and spilled

I love this stuff. I went this brand due to their quality control process and it has been great for me. I know it may sound far fetched but it really helped to correct some of my gastric distress issues.